Therapy of lymphogranuloma inguinale with 7218.

The demonstration by Hurst and others (1953) of the effectiveness of quinoxaline-1: 4-dioxide and certain of its substituted derivatives against lymphogranuloma inguinale in mice and in developing chick embryos led to a request for the trial of one of the most active of these compounds in human lymphogranuloma. The selected compound was 2: 3 dimethyl quinoxaline-l : 4-dioxide (7218). This paper records our experiences in the administration of 7218 to an unselected series of cases of lymphogranuloma inguinale together with certain observations on the effects of administering the drug to healthy adults.